Simmonds Disease

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Simmonds Disease- Primary pituitary insufficiency, in which the secretion of the majority of the hypophysial hormones is reduced, with secondary hypofunction of the peripheral endocrine glands.

Etiology

  • Hypo- or atrophy of the anterior pituitary gland
  • Hypothalamic liberin deficiency
  • Injuries
  • Infection (sepsis, encephalitis, tuberculosis, syphilis)
  • Vascular disorders (spasm, collapse).

The clinical picture depends on the degree of reduction in the functions of the pituitary gland.

  1. Sharp weight loss - the dominant symptom of the disease
  2. Symptoms of thyroid insufficiency, gonads, adrenal cortex.

The diagnosis is based on anamnestic data, the clinic, a decrease in the content of 17-oxycorticosteroids in the blood and daily urine, low concentrations of TSH, T3, T4 in plasma. X-ray examination of the spine- not often occurrences of osteoporosis.

Treatment:

  • Diet with the introduction of a sufficient amount of proteins, fats, vitamins.
  • Hormone replacement therapy
  • Somatotropin to stimulate the growth of babies
  • Glucocorticoids. In domestic practice, prednisone is often used at 5-10 mg / day with an increase in dose during stress. With a decrease in blood pressure, low sodium content and a high content of potassium in the serum, on the background of taking prednisolone, mineralocorticoids are additionally prescribed (for example, deoxycorticosterone acetate 5 mg 2-3 r / week parenteral or 5-15 mg / day 1-3 r / day under the tongue)
  • Sex hormones: the estrogen-progesterone combination helps to normalize menstrual function, and testosterone is prescribed to men to restore libido and potency
  • Thyroidinhormones, for example levothyroxine
  • Anabolic steroid.

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