Wasserman reaction

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Wasserman reaction(it. microbiologist-immunologist, 1866-1925), RW -method of serodiagnosis of syphilis.

Developed in 1906. Based on the property of the serum of patients with syphilis, in contrast to the serum of healthy individuals, to form a complex that adsorbs complement with the corresponding antigen. V. p. conduct, adding an indicator system consisting of erythrocytes ram and hemolytic. serum, to the studied serum.
Lack of hemolysis is indicativeabout complement absorption, to-ry was added to the mixture of the serum and antigen under study, and, therefore, about the formation of the corresponding complex (positive reaction).
The onset of hemolysis indicates the presence of free complement, that is, the lack of interaction between the serum and the antigen (negative reaction).
In pregnancy, false positive reactions may occur in 2% of cases. V. p. held at the first visit to a pregnant woman consultation, then with a gestational age of 32 weeks. V. p. also used in the diagnosis of active forms of congenital syphilis.

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